Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 8/20 | 0.43 |
| ▸ | ST14 | Q9Y5Y6 | 5/20 | 0.40 |
| ▸ | F10 | P00742 | 4/20 | 0.40 |
| ▸ | PLG | P00747 | 4/20 | 0.40 |
| ▸ | PLAU | P00749 | 4/20 | 0.40 |
| ▸ | MMP9 | P14780 | 3/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | HPN | P05981 | 1/20 | 0.35 |
| ▸ | HGFAC | Q04756 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MMP12 | P39900 | 1/20 | 0.34 |
| ▸ | MMP14 | P50281 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7306256 | 0.91 | F2 (0.41) | F2ST14F10PLGPLAU | |
| SCHEMBL7300402 | 0.88 | F2 (0.48) | F2ST14F10PLGPLAU | |
| SCHEMBL27383153 | 0.80 | F2 (0.47) | F2ST14F10PLGPLAU | |
| Hydrochloric Acid SCHEMBL8947669 | 0.80 | F2 (0.47) | F2ST14F10PLGPLAU | |
| SCHEMBL7303162 | 0.78 | F2 (0.44) | F2 | |
| SCHEMBL7305122 | 0.77 | F2 (0.59) | F2 | |
| SCHEMBL7294199 | 0.76 | F2 (0.44) | F2 | |
| SCHEMBL7299071 | 0.76 | MMP2 (0.40) | F2ST14MMP9MMP2HPN | |
| SCHEMBL7294015 | 0.75 | MMP2 (0.39) | F2ST14MMP9MMP2HPN | |
| SCHEMBL7299083 | 0.74 | F2 (0.44) | F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559046-B1 | N-amidinopiperidinyl(3/4)- or N-amidino-1,4-Oxazinyl(2)-substituted sulfonamides, process for their preparation and use as thrombin inhibitors | HOFFMANN LA ROCHE (CH) | 2001-07-11 | — | — | EP | disclosed |
| US-5578594-A | ANTICOAGULANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-11-26 | — | — | US | disclosed |
| US-5405854-A | Anticoagulants | HOFFMANN-LA ROCHE INC. (US) | 1995-04-11 | — | — | US | disclosed |
| EP-0559046-A1 | N-amidinopiperidinyl(3/4)- or N-amidino-1,4-Oxazinyl(2)-substituted sulfonamides, process for their preparation and use as thrombin inhibitors | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1993-09-08 | — | — | EP | disclosed |