Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | THPO | P40225 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19486076 | 0.75 | ALDH1A1 (0.38) | ALDH1A1ADAM17MEN1KMT2ADPP4 | |
| SCHEMBL13625970 | 0.75 | ALDH1A1 (0.38) | ALDH1A1ADAM17MEN1KMT2ADPP4 | |
| SCHEMBL7292999 | 0.74 | ELANE (0.44) | DPP4DPP8DPP9ELANE | |
| SCHEMBL8746308 | 0.72 | ELANE (0.43) | DPP4DPP8DPP9ELANE | |
| Hydrochloric Acid SCHEMBL7303909 | 0.72 | ELANE (0.43) | DPP4DPP8DPP9ELANE | |
| SCHEMBL21543932 | 0.70 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL6995147 | 0.69 | HTT (0.32) | — | |
| SCHEMBL8130071 | 0.69 | DPP4 (0.43) | ALDH1A1ADAM17MEN1KMT2ADPP4 | |
| SCHEMBL15368410 | 0.69 | DPP4 (0.43) | ALDH1A1ADAM17MEN1KMT2ADPP4 | |
| SCHEMBL13018857 | 0.69 | DPP4 (0.43) | ALDH1A1ADAM17MEN1KMT2ADPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509769-B1 | Heterocyclic amides having HLE inhibiting activity | ZENECA LTD (GB) | 1996-09-11 | — | — | EP | disclosed |