Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 6/20 | 0.60 |
| ▸ | PSMB1 | P20618 | 5/20 | 0.60 |
| ▸ | PSMB2 | P49721 | 5/20 | 0.60 |
| ▸ | ANPEP | P15144 | 5/20 | 0.54 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | FCER2 | P06734 | 1/20 | 0.45 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7300546 | 1.00 | PSMB5 (0.60) | PSMB5PSMB1PSMB2ANPEPHTRA1 | |
| SCHEMBL7300779 | 0.87 | REN (0.51) | PSMB5PSMB1PSMB2 | |
| SCHEMBL7300785 | 0.87 | REN (0.51) | PSMB5PSMB1PSMB2 | |
| SCHEMBL7300553 | 0.86 | PSMB5 (0.51) | PSMB5PSMB1PSMB2ANPEPMMP8 | |
| SCHEMBL7301724 | 0.86 | PSMB5 (0.47) | PSMB5PSMB1PSMB2ANPEP | |
| SCHEMBL7301741 | 0.86 | PSMB5 (0.47) | PSMB5PSMB1PSMB2ANPEP | |
| SCHEMBL7301731 | 0.86 | PSMB5 (0.47) | PSMB5PSMB1PSMB2ANPEP | |
| SCHEMBL7429195 | 0.85 | TSHR (0.46) | PSMB5PSMB1PSMB2FCER2 | |
| SCHEMBL7430388 | 0.85 | CAPN1 (0.48) | PSMB5PSMB1PSMB2HTRA1 | |
| SCHEMBL7303217 | 0.85 | CAPN1 (0.48) | PSMB5PSMB1PSMB2HTRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525420-B1 | Pseudopeptides and dipeptides characterised by a substituted methyl ketone moiety at the C-terminus as thiol protease inhibitors | MITSUBISHI CHEM CORP (JP) | 1999-05-12 | — | — | EP | disclosed |
| US-5639783-A | POTENT PROTEASE INHIBITOR FOR TREATING MUSCULAR, NERVOUS SYSTEM DISEASES | MITSUBISHI CHEMICAL CORPORATION (JP) | 1997-06-17 | — | — | US | disclosed |
| EP-0525420-A1 | Pseudopeptides and dipeptides characterised by a substituted methyl ketone moiety at the C-terminus as thiol protease inhibitors | Mitsubishi Chemical Corporation (JP) | 1993-02-03 | — | — | EP | disclosed |