Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 6/20 | 0.47 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.47 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.47 |
| ▸ | REN | P00797 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.42 |
| ▸ | CYP3A7 | P24462 | 1/20 | 0.42 |
| ▸ | CYP3A43 | Q9HB55 | 1/20 | 0.42 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | TMPRSS11D | O60235 | 1/20 | 0.41 |
| ▸ | CTRL | P40313 | 1/20 | 0.41 |
| ▸ | ANPEP | P15144 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7301741 | 1.00 | PSMB5 (0.47) | PSMB5PSMB1PSMB2RENCYP3A4 | |
| SCHEMBL7301731 | 1.00 | PSMB5 (0.47) | PSMB5PSMB1PSMB2RENCYP3A4 | |
| SCHEMBL7312126 | 0.95 | CTSG (0.46) | PSMB5PSMB1PSMB2RENCYP3A4 | |
| SCHEMBL7312135 | 0.95 | CTSG (0.46) | PSMB5PSMB1PSMB2RENCYP3A4 | |
| SCHEMBL7300785 | 0.91 | REN (0.51) | PSMB5PSMB1PSMB2REN | |
| SCHEMBL7300779 | 0.91 | REN (0.51) | PSMB5PSMB1PSMB2REN | |
| SCHEMBL7346557 | 0.91 | CTSG (0.48) | CTSLCTSB | |
| SCHEMBL7346551 | 0.91 | CTSG (0.48) | CTSLCTSB | |
| SCHEMBL7303784 | 0.87 | ALDH1A1 (0.49) | PSMB5PSMB1PSMB2REN | |
| SCHEMBL7303430 | 0.87 | PSMB5 (0.45) | PSMB5PSMB1PSMB2REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525420-B1 | Pseudopeptides and dipeptides characterised by a substituted methyl ketone moiety at the C-terminus as thiol protease inhibitors | MITSUBISHI CHEM CORP (JP) | 1999-05-12 | — | — | EP | disclosed |
| US-5639783-A | POTENT PROTEASE INHIBITOR FOR TREATING MUSCULAR, NERVOUS SYSTEM DISEASES | MITSUBISHI CHEMICAL CORPORATION (JP) | 1997-06-17 | — | — | US | disclosed |
| EP-0525420-A1 | Pseudopeptides and dipeptides characterised by a substituted methyl ketone moiety at the C-terminus as thiol protease inhibitors | Mitsubishi Chemical Corporation (JP) | 1993-02-03 | — | — | EP | disclosed |