Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 9/20 | 0.61 |
| ▸ | MMP9 | P14780 | 6/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.56 |
| ▸ | F2 | P00734 | 4/20 | 0.55 |
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
| ▸ | CNR2 | P34972 | 1/20 | 0.52 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MMP1 | P03956 | 1/20 | 0.51 |
| ▸ | MMP3 | P08254 | 1/20 | 0.51 |
| ▸ | MMP7 | P09237 | 1/20 | 0.51 |
| ▸ | MMP13 | P45452 | 1/20 | 0.51 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9710605 | 1.00 | MMP2 (0.61) | MMP2MMP9POLBADAMTS4F2 | |
| SCHEMBL7566084 | 0.89 | MMP2 (0.58) | MMP2MMP9POLBADAMTS4F2 | |
| SCHEMBL18049375 | 0.89 | MMP2 (0.58) | MMP2MMP9POLBADAMTS4F2 | |
| SCHEMBL3310154 | 0.88 | MMP2 (0.71) | MMP2MMP9POLBADAMTS4F2 | |
| SCHEMBL7290941 | 0.88 | MMP2 (0.71) | MMP2MMP9POLBADAMTS4F2 | |
| SCHEMBL31086814 | 0.88 | MMP2 (0.71) | MMP2MMP9POLBADAMTS4F2 | |
| SCHEMBL5189194 | 0.88 | MMP2 (0.71) | MMP2MMP9POLBADAMTS4F2 | |
| SCHEMBL7983901 | 0.88 | F2 (0.55) | MMP2MMP9POLBF2CNR1 | |
| SCHEMBL9710396 | 0.88 | CTSS (0.56) | MMP2MMP9POLBF2CNR1 | |
| SCHEMBL8489662 | 0.87 | F2 (0.64) | F2CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5763436-A | ANTICOAGULANTS | HOFFMANN-LA ROCHE INC. (US) | 1998-06-09 | — | — | US | disclosed |
| US-5595999-A | ANTICOAGULANTS | HOFFMANN-LA ROCHE INC. (US) | 1997-01-21 | — | — | US | disclosed |
| US-5583133-A | ANTICOAGULANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-12-10 | — | — | US | disclosed |
| US-5532232-A | INHIBIT THROMBIN INDUCED PLATELET AGGREGATION; FIBRINOGEN ANTICOAGULANTS IN BLOOD | HOFFMANN-LA ROCHE INC. (US) | 1996-07-02 | — | — | US | disclosed |
| US-5393760-A | Cardiovascular disorders, antitumor agents | HOFFMANN-LA ROCHE INC. (US) | 1995-02-28 | — | — | US | disclosed |
| EP-0468231-B1 | Guanidins | HOFFMANN LA ROCHE (CH) | 1994-09-21 | — | — | EP | disclosed |
| US-5260307-A | Inhibit thrombin-induced platlet aggregation and clotting of fibrogen in plasma | HOFMANN-LA ROCHE INC. (US) | 1993-11-09 | — | — | US | disclosed |
| EP-0468231-A2 | Guanidins | F. HOFFMANN-LA ROCHE AG (CH) | 1992-01-29 | — | — | EP | disclosed |