Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | ELANE | P08246 | 2/20 | 0.55 |
| ▸ | CTSS | P25774 | 8/20 | 0.54 |
| ▸ | CTSL | P07711 | 7/20 | 0.54 |
| ▸ | CTSK | P43235 | 6/20 | 0.54 |
| ▸ | CTSB | P07858 | 5/20 | 0.54 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.52 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1152786 | 1.00 | ATM (0.56) | ATMELANECTSSCTSLCTSK | |
| SCHEMBL28216854 | 0.91 | CTSK (0.56) | ATMELANECTSSCTSLCTSK | |
| SCHEMBL7181654 | 0.90 | CTSS (0.57) | CTSSCTSLCTSKCTSB | |
| SCHEMBL7183454 | 0.90 | CTSS (0.57) | CTSSCTSLCTSKCTSB | |
| SCHEMBL4092509 | 0.89 | ELANE (0.51) | ATMELANECTSSCTSLCTSK | |
| SCHEMBL16834866 | 0.88 | ATM (0.56) | ATMELANECTSSCTSLCTSK | |
| SCHEMBL16846451 | 0.88 | ATM (0.56) | ATMELANECTSSCTSLCTSK | |
| SCHEMBL8211096 | 0.87 | CTSS (0.61) | ATMELANECTSSCTSLCTSK | |
| SCHEMBL7307319 | 0.87 | CTSS (0.61) | ATMELANECTSSCTSLCTSK | |
| SCHEMBL7307315 | 0.87 | CTSS (0.61) | ATMELANECTSSCTSLCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5807870-A | SIDE EFFECT REDUCTION | BIOMEGA BOEHRINGER INGELHEIM RESEARCH LTD. (CA) | 1998-09-15 | — | — | US | disclosed |
| EP-0594540-B1 | Antiretroviral acyl compounds | CIBA GEIGY AG (CH) | 1998-04-01 | — | — | EP | disclosed |
| US-5614533-A | Substituted pipecolinic acid derivatives as HIV protease inhibitors | BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH, INC. (CA) | 1997-03-25 | — | — | US | disclosed |
| WO-1996016980-A1 | MORPHOLINOETHYLAMIDE DERIVATIVES | NOVARTIS AG (CH) | 1996-06-06 | — | — | WO | disclosed |
| EP-0594540-A1 | Antiretroviral acyl compounds | CIBA-GEIGY AG (CH) | 1994-04-27 | — | — | EP | disclosed |