Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | REN | P00797 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.44 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2295759 | 1.00 | KMT2A (0.49) | KMT2AMEN1ALDH1A1HPGDKDM4E | |
| SCHEMBL5709588 | 1.00 | KMT2A (0.49) | KMT2AMEN1ALDH1A1HPGDKDM4E | |
| SCHEMBL7433845 | 0.89 | KDM4E (0.45) | KMT2AMEN1ALDH1A1HPGDKDM4E | |
| SCHEMBL11981992 | 0.89 | REN (0.48) | KMT2AMEN1ALDH1A1HPGDKDM4E | |
| SCHEMBL13840602 | 0.89 | REN (0.48) | KMT2AMEN1ALDH1A1HPGDKDM4E | |
| SCHEMBL7433838 | 0.89 | KDM4E (0.45) | KMT2AMEN1ALDH1A1HPGDKDM4E | |
| SCHEMBL10751934 | 0.89 | CTNNB1 (0.47) | KMT2AMEN1ALDH1A1HPGDKDM4E | |
| SCHEMBL7289410 | 0.89 | CTNNB1 (0.47) | KMT2AMEN1ALDH1A1HPGDKDM4E | |
| SCHEMBL421814 | 0.88 | REN (0.48) | KMT2AMEN1ALDH1A1HPGDKDM4E | |
| SCHEMBL13839332 | 0.88 | REN (0.48) | KMT2AMEN1ALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5250517-A | Hypotensive and cardiotonic agents; cardiac insufficiency | HOFFMANN-LA ROCHE INC. (US) | 1993-10-05 | — | — | US | disclosed |
| EP-0416393-A1 | Peptidyl difluorodiol renin inhibitors | ABBOTT LABORATORIES (US) | 1991-03-13 | — | — | EP | disclosed |
| EP-0341602-A2 | Renin-inhibiting functionalized peptidyl aminodiols and - triols | ABBOTT LABORATORIES (US) | 1989-11-15 | — | — | EP | disclosed |
| US-4826958-A | HYPOTENSIVE AGENTS | ABBOTT LABORATORIES (US) | 1989-05-02 | — | — | US | disclosed |