Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 11/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 7/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.34 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9271889 | 0.75 | SMN1; SMN2 (0.43) | SMN1; SMN2HTR1AADRA1BADRA1ADRD2 | |
| SCHEMBL7709836 | 0.75 | SMN1; SMN2 (0.47) | SMN1; SMN2HTR1AADRA1BADRA1ADRD2 | |
| SCHEMBL14820495 | 0.73 | SMN1; SMN2 (0.46) | SMN1; SMN2HTR1AADRA1BADRA1ADRD2 | |
| SCHEMBL3379242 | 0.73 | SMN1; SMN2 (0.46) | SMN1; SMN2HTR1AADRA1BADRA1ADRD2 | |
| SCHEMBL7835878 | 0.73 | SMN1; SMN2 (0.42) | SMN1; SMN2HTR1AADRA1BADRA1ADRD2 | |
| SCHEMBL14806816 | 0.72 | SMN1; SMN2 (0.41) | SMN1; SMN2HTR1AADRA1BADRA1ADRD2 | |
| SCHEMBL14806790 | 0.70 | SMN1; SMN2 (0.40) | SMN1; SMN2HTR1AADRA1BADRA1ADRD2 | |
| SCHEMBL10299522 | 0.70 | SMN1; SMN2 (0.43) | SMN1; SMN2HTR1AADRA1BADRA1ADRD2 | |
| SCHEMBL11930032 | 0.70 | SMN1; SMN2 (0.43) | SMN1; SMN2HTR1AADRA1BADRA1ADRD2 | |
| SCHEMBL12601433 | 0.70 | CHRM2 (0.46) | SMN1; SMN2HTR1AADRA1BADRA1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5395841-A | 4-benzylpiperidines for treating phychosis | FERRER INTERNACIONAL, S.A. (ES) | 1995-03-07 | — | — | US | claimed |
| EP-0572952-A1 | 4-Benzylpiperidine derivatives, a process for preparing them and pharmaceutical compositions containing them | FERRER INTERNACIONAL, S.A. (ES) | 1993-12-08 | — | — | EP | claimed |
| JP-6172308-A | — | — | None | — | — | JP | disclosed |
| US-5395841-A | 4-benzylpiperidines for treating phychosis | FERRER INTERNACIONAL, S.A. (ES) | 1995-03-07 | — | — | US | disclosed |
| US-5395841-A | 4-benzylpiperidines for treating phychosis | FERRER INTERNACIONAL, S.A. (ES) | 1995-03-07 | — | — | US | disclosed |
| JP-H06172308-A | 4-BENZYLPIPERIDINE DERIVATIVE, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE DERIVATIVE | FERRER INTERNATL SA | 1994-06-21 | — | — | JP | disclosed |
| EP-0572952-A1 | 4-Benzylpiperidine derivatives, a process for preparing them and pharmaceutical compositions containing them | FERRER INTERNACIONAL, S.A. (ES) | 1993-12-08 | — | — | EP | disclosed |