Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.65 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.61 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.61 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7294862 | 0.91 | TRPV1 (0.68) | TRPV1HDAC3HDAC11HDAC8HDAC6 | |
| SCHEMBL7303163 | 0.83 | HDAC3 (0.86) | TRPV1HDAC3HDAC11HDAC8HDAC6 | |
| SCHEMBL7304276 | 0.82 | NPC1 (0.81) | TRPV1HDAC3HDAC11HDAC8HDAC6 | |
| SCHEMBL7301192 | 0.82 | NPC1 (0.81) | TRPV1HDAC3HDAC11HDAC8HDAC6 | |
| SCHEMBL2546366 | 0.81 | NR1H4 (0.46) | NR1H4SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL14860277 | 0.80 | MAPT (0.62) | TRPV1NR1H4SMN1; SMN2NPC1RAB9A | |
| SCHEMBL7296425 | 0.79 | NR1H4 (0.76) | TRPV1HDAC3HDAC11HDAC8HDAC6 | |
| SCHEMBL7302042 | 0.79 | HDAC3 (0.73) | TRPV1HDAC3HDAC11HDAC8HDAC6 | |
| SCHEMBL7302201 | 0.78 | NPC1 (0.74) | TRPV1HDAC3HDAC11HDAC8HDAC6 | |
| SCHEMBL30994893 | 0.78 | PGR (0.74) | TRPV1HDAC3HDAC11HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0358118-B1 | Phenylamides - process for their preparation as well as a drug containing those compounds | BOEHRINGER MANNHEIM GMBH (DE) | 1994-03-16 | — | — | EP | disclosed |
| US-5135949-A | Anticoagulants | BOEHRINGER MANNHEIM GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0358118-A1 | Phenylamides - process for their preparation as well as a drug containing those compounds | Roche Diagnostics GmbH (DE) | 1990-03-14 | — | — | EP | disclosed |