Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.81 |
| ▸ | RAB9A | P51151 | 6/20 | 0.81 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.81 |
| ▸ | TP53 | P04637 | 4/20 | 0.81 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.81 |
| ▸ | MAPT | P10636 | 3/20 | 0.73 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.71 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.69 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.69 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.69 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | APEX1 | P27695 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | RECQL | P46063 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7304276 | 1.00 | NPC1 (0.81) | NPC1RAB9ASMN1; SMN2TP53ALOX15 | |
| SCHEMBL6799157 | 0.90 | RAB9A (1.00) | NPC1RAB9ASMN1; SMN2TP53ALOX15 | |
| SCHEMBL28563499 | 0.89 | MAPK1 (0.67) | NPC1RAB9ASMN1; SMN2TP53ALOX15 | |
| SCHEMBL7303163 | 0.88 | HDAC3 (0.86) | NPC1RAB9ASMN1; SMN2MAPTTRPV1 | |
| SCHEMBL5223218 | 0.87 | NR1H4 (0.73) | NPC1RAB9ASMN1; SMN2TP53ALOX15 | |
| SCHEMBL18739771 | 0.86 | NPC1 (0.59) | NPC1RAB9ASMN1; SMN2TP53ALOX15 | |
| SCHEMBL6258773 | 0.86 | MAPT (0.65) | NPC1RAB9ASMN1; SMN2TP53ALOX15 | |
| SCHEMBL7296804 | 0.86 | SMN1; SMN2 (0.77) | NPC1RAB9ASMN1; SMN2TP53ALOX15 | |
| SCHEMBL2347796 | 0.86 | ALDH1A1 (0.67) | NPC1RAB9ASMN1; SMN2TP53ALOX15 | |
| SCHEMBL15149791 | 0.86 | MAPT (0.62) | NPC1RAB9ASMN1; SMN2TP53ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7667036-B2 | MAPKAP-K2 (mitogen-activated protein kinase-activated protein kinase 2) inhibitors; inflammatory, autoimmune disease, destructive bone disorder, cancer and/or tumor growth; angiogenesis, diabetes and neurological disorders | TEIJIN PHARMA LIMITED (JP) | 2010-02-23 | — | — | US | disclosed |
| US-7667036-B2 | MAPKAP-K2 (mitogen-activated protein kinase-activated protein kinase 2) inhibitors; inflammatory, autoimmune disease, destructive bone disorder, cancer and/or tumor growth; angiogenesis, diabetes and neurological disorders | TEIJIN PHARMA LIMITED (JP) | 2010-02-23 | — | — | US | disclosed |
| EP-0358118-B1 | Phenylamides - process for their preparation as well as a drug containing those compounds | BOEHRINGER MANNHEIM GMBH (DE) | 1994-03-16 | — | — | EP | disclosed |
| US-5135949-A | Anticoagulants | BOEHRINGER MANNHEIM GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0358118-A1 | Phenylamides - process for their preparation as well as a drug containing those compounds | Roche Diagnostics GmbH (DE) | 1990-03-14 | — | — | EP | disclosed |