Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 5/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | SCD | O00767 | 6/20 | 0.45 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.44 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7299471 | 0.84 | MME (0.52) | MMEALDH1A1PDE5ASMN1; SMN2TP53 | |
| SCHEMBL7346217 | 0.81 | MME (0.69) | MMEALDH1A1SCDITGB1ITGA4 | |
| SCHEMBL7301495 | 0.77 | MME (0.60) | MMEALDH1A1SCDITGB1ITGA4 | |
| SCHEMBL7302170 | 0.76 | MME (0.54) | MMEALDH1A1SCDITGB1ITGA4 | |
| SCHEMBL7298781 | 0.74 | MME (0.55) | MMEALDH1A1SCDITGB1ITGA4 | |
| SCHEMBL1916535 | 0.73 | MME (0.58) | MMEALDH1A1PDE5ATP53MAPK1 | |
| SCHEMBL1916530 | 0.73 | MME (0.58) | MMEALDH1A1PDE5ATP53MAPK1 | |
| SCHEMBL7307957 | 0.73 | MME (0.56) | MMEALDH1A1 | |
| SCHEMBL7348891 | 0.70 | LMNA (0.57) | ALDH1A1SMN1; SMN2TP53L3MBTL1 | |
| SCHEMBL7438793 | 0.70 | MME (0.59) | MMEALDH1A1SCDITGB1ITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636630-B1 | N-heteroaryl substituted derivatives of propanamide useful in the treatment of cardiovascular diseases | ZAMBON SPA (IT) | 1999-04-28 | — | — | EP | disclosed |
| US-5438046-A | Enzyme inhibitors | ZAMBON GROUP S.P.A. (IT) | 1995-08-01 | — | — | US | disclosed |
| EP-0636630-A1 | N-heteroaryl substituted derivatives of propanamide useful in the treatment of cardiovascular diseases | ZAMBON GROUP S.p.A. (IT) | 1995-02-01 | — | — | EP | disclosed |