Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 5/20 | 0.56 |
| ▸ | CTSS | P25774 | 7/20 | 0.55 |
| ▸ | CTSK | P43235 | 6/20 | 0.55 |
| ▸ | CTSB | P07858 | 3/20 | 0.55 |
| ▸ | CTSL | P07711 | 1/20 | 0.55 |
| ▸ | PTPRB | P23467 | 2/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | AKT1 | P31749 | 1/20 | 0.49 |
| ▸ | ACE | P12821 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CCKAR | P32238 | 1/20 | 0.47 |
| ▸ | CCKBR | P32239 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7306211 | 0.91 | CTSS (0.52) | MMECTSSCTSKCTSBCTSL | |
| SCHEMBL7308841 | 0.90 | LMNA (0.56) | CTSSCTSKCTSBCTSLPTPRB | |
| SCHEMBL3814091 | 0.86 | CTSS (0.57) | CTSSCTSKCTSBCTSLPTPRB | |
| SCHEMBL27677878 | 0.86 | CTSS (0.57) | CTSSCTSKCTSBCTSLPTPRB | |
| SCHEMBL3815763 | 0.84 | CTSS (0.55) | CTSSCTSKCTSBCTSLPTPRB | |
| SCHEMBL3815756 | 0.84 | CTSS (0.55) | CTSSCTSKCTSBCTSLPTPRB | |
| SCHEMBL7308721 | 0.81 | MAPT (0.58) | CTSSCTSKPTPRBALDH1A1 | |
| SCHEMBL299175 | 0.80 | SMN1; SMN2 (0.51) | ALDH1A1 | |
| SCHEMBL16434228 | 0.79 | NPSR1 (0.53) | CTSSCTSKCTSBCTSLPTPRB | |
| SCHEMBL7443382 | 0.79 | TACR1 (0.53) | MMECTSSCTSKCTSBCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636630-B1 | N-heteroaryl substituted derivatives of propanamide useful in the treatment of cardiovascular diseases | ZAMBON SPA (IT) | 1999-04-28 | — | — | EP | disclosed |
| US-5438046-A | Enzyme inhibitors | ZAMBON GROUP S.P.A. (IT) | 1995-08-01 | — | — | US | disclosed |
| EP-0636630-A1 | N-heteroaryl substituted derivatives of propanamide useful in the treatment of cardiovascular diseases | ZAMBON GROUP S.p.A. (IT) | 1995-02-01 | — | — | EP | disclosed |