Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 2/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7272185 | 1.00 | REN (0.49) | RENTP53KDM4EGMNNLMNA | |
| Acetic Acid SCHEMBL7300070 | 0.90 | REN (0.49) | RENMETAP2METAP1 | |
| SCHEMBL12507498 | 0.86 | REN (0.49) | RENMETAP2METAP1 | |
| SCHEMBL7272557 | 0.85 | REN (0.49) | RENLMNAMETAP2METAP1 | |
| SCHEMBL8910518 | 0.85 | REN (0.49) | RENLMNAMETAP2METAP1 | |
| Hydrochloric Acid SCHEMBL9848324 | 0.84 | REN (0.47) | RENTP53KDM4EGMNNLMNA | |
| SCHEMBL7277378 | 0.84 | REN (0.47) | RENTP53METAP2METAP1 | |
| SCHEMBL10591623 | 0.83 | REN (0.46) | RENTP53KDM4EGMNNLMNA | |
| SCHEMBL7274162 | 0.83 | REN (0.55) | RENMETAP2METAP1 | |
| SCHEMBL7265219 | 0.83 | REN (0.48) | RENMETAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1989010751-A1 | FUNCTIONALIZED PEPTIDYL AMINODIOLS AND -TRIOLS | ABBOTT LABORATORIES (US) | 1989-11-16 | — | — | WO | disclosed |
| EP-0341602-A2 | Renin-inhibiting functionalized peptidyl aminodiols and - triols | ABBOTT LABORATORIES (US) | 1989-11-15 | — | — | EP | disclosed |