Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 7/20 | 0.56 |
| ▸ | NPC1 | O15118 | 6/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | MAOB | P27338 | 1/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.56 |
| ▸ | XIAP | P98170 | 1/20 | 0.55 |
| ▸ | ALPL | P05186 | 1/20 | 0.55 |
| ▸ | ALPI | P09923 | 1/20 | 0.55 |
| ▸ | ALPG | P10696 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | MITF | O75030 | 1/20 | 0.55 |
| ▸ | KLF5 | Q13887 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1106998 | 0.85 | LMNA (0.69) | LMNAFFAR2CYP3A4RAB9ANPC1 | |
| SCHEMBL1121189 | 0.81 | HSD17B10 (0.66) | LMNAFFAR2CYP3A4RAB9ANPC1 | |
| SCHEMBL11578322 | 0.79 | HSD17B10 (0.67) | LMNAFFAR2CYP3A4RAB9ANPC1 | |
| Benzene SCHEMBL7282826 | 0.78 | NPC1 (0.60) | LMNAFFAR2CYP3A4RAB9ANPC1 | |
| SCHEMBL30968980 | 0.77 | LMNA (1.00) | LMNACYP3A4RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL29776932 | 0.77 | CYP3A4 (1.00) | LMNACYP3A4RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL707208 | 0.77 | CYP3A4 (1.00) | LMNACYP3A4RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL1434166 | 0.77 | LMNA (1.00) | LMNACYP3A4RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL23566380 | 0.77 | NPC1 (0.75) | LMNACYP3A4RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4236216 | 0.77 | CYP3A4 (0.65) | LMNAFFAR2CYP3A4RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0337714-A2 | HIV protease inhibitors useful for the treatment of aids | MERCK & CO. INC. (US) | 1989-10-18 | — | — | EP | claimed |
| EP-0337714-A2 | HIV protease inhibitors useful for the treatment of aids | MERCK & CO. INC. (US) | 1989-10-18 | — | — | EP | disclosed |