Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 18/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 15/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 11/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL898138 | 0.83 | SLC6A3 (0.39) | SLC6A3SLC6A2SLC6A4HRH3 | |
| Iodide SCHEMBL15008876 | 0.81 | SLC6A3 (0.38) | SLC6A3SLC6A2SLC6A4HRH3 | |
| SCHEMBL3302667 | 0.81 | SLC6A3 (0.38) | SLC6A3SLC6A2SLC6A4HRH3 | |
| SCHEMBL13182550 | 0.81 | SLC6A3 (0.32) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL22701318 | 0.79 | SLC6A3 (0.35) | SLC6A3SLC6A2SLC6A4HRH3 | |
| SCHEMBL14160126 | 0.75 | HRH3 (0.40) | SLC6A3SLC6A2SLC6A4HRH3 | |
| SCHEMBL2229569 | 0.74 | SLC6A3 (0.37) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL24869964 | 0.74 | HRH3 (0.42) | SLC6A3SLC6A2SLC6A4HRH3 | |
| SCHEMBL18403963 | 0.74 | SLC6A3 (0.34) | SLC6A3SLC6A2SLC6A4HRH3 | |
| SCHEMBL14204509 | 0.74 | HRH3 (0.42) | SLC6A3SLC6A2SLC6A4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5378691-A | Amino acid derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-01-03 | — | — | US | disclosed |
| EP-0501280-A2 | Renin-inhibiting peptide analogues | MERCK PATENT GmbH (DE) | 1992-09-02 | — | — | EP | disclosed |
| EP-0446485-A2 | Peptide analogues with renininhibiting activity | MERCK PATENT GmbH (DE) | 1991-09-18 | — | — | EP | disclosed |
| EP-0418696-A2 | Derivatives of aminoacids | MERCK PATENT GmbH (DE) | 1991-03-27 | — | — | EP | disclosed |
| EP-0339483-A2 | Renin inhbiting amino-acid derivatives | MERCK PATENT GmbH (DE) | 1989-11-02 | — | — | EP | disclosed |