Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 18/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 15/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MLNR | O43193 | 1/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6446932 | 0.78 | ALDH1A1 (0.42) | SLC6A4SLC6A2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL6446653 | 0.77 | KDM4E (0.42) | SLC6A4SLC6A2SLC6A3KDM4EALDH1A1 | |
| SCHEMBL6447975 | 0.76 | HTR1B (0.56) | SLC6A4SLC6A2ADRB1HTR2AHRH1 | |
| SCHEMBL6451495 | 0.76 | SLC6A4 (0.42) | SLC6A4SLC6A2SLC6A3KDM4EALDH1A1 | |
| SCHEMBL6445561 | 0.76 | KDM4E (0.50) | SLC6A4SLC6A2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL6443698 | 0.74 | ALDH1A1 (0.45) | SLC6A4SLC6A2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL27322002 | 0.70 | CYP1A2 (0.49) | SLC6A4SLC6A2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL6447404 | 0.70 | BTN3A1 (0.44) | SLC6A4SLC6A2KDM4EALDH1A1 | |
| SCHEMBL5000089 | 0.69 | SLC6A4 (0.65) | SLC6A4SLC6A2SLC6A3MLNRCACNA1F | |
| SCHEMBL6446149 | 0.68 | CASP1 (0.47) | SLC6A4SLC6A2KDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0521827-B1 | Pharmacological active hydrazin derivatives and process for their preparation | CIBA GEIGY AG (CH) | 1996-09-25 | — | — | EP | disclosed |