Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | ESRRG | P62508 | 1/20 | 0.52 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.49 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL242050 | 0.92 | MAPT (0.59) | TRPV6MEN1KMT2AMAPTCYP2C19 | |
| SCHEMBL6610401 | 0.86 | MEN1 (0.59) | TRPV6MEN1KMT2AMAPTCYP2C19 | |
| SCHEMBL6714666 | 0.84 | MAPT (0.53) | TRPV6MEN1KMT2AMAPTCYP2C19 | |
| SCHEMBL4336239 | 0.82 | L3MBTL3 (0.69) | MEN1KMT2AMAPTPOLBCYP2D6 | |
| SCHEMBL3513864 | 0.82 | SLC18A3 (0.65) | TRPV6MEN1KMT2AMAPTCYP2C19 | |
| SCHEMBL8438403 | 0.81 | SLC18A3 (0.62) | CYP2C9SLC18A3CYP2D6ALDH1A1 | |
| SCHEMBL77340 | 0.81 | MAPT (0.71) | MEN1KMT2AMAPTPOLBCYP2D6 | |
| SCHEMBL3574460 | 0.81 | MAPT (0.71) | MEN1KMT2AMAPTPOLBCYP2D6 | |
| SCHEMBL7300130 | 0.81 | MAPT (0.55) | MEN1KMT2AMAPTCYP2C19POLB | |
| SCHEMBL521556 | 0.80 | KMT2A (0.64) | MEN1KMT2AMAPTPOLBL3MBTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0503411-B1 | Substituted N-phenylpiperidines and medicaments thereof | BASF AG (DE) | 1995-11-29 | — | — | EP | disclosed |
| US-5296485-A | Substituted N-phenylpiperidines and drugs therefrom | BASF AKTIENGESELLSCHAFT (DE) | 1994-03-22 | — | — | US | disclosed |