Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7294598 | 0.89 | CYP26A1 (0.44) | CYP26A1CYP19A1SIGMAR1CA1CA2 | |
| SCHEMBL7295069 | 0.87 | CYP26A1 (0.42) | CYP26A1CYP19A1SIGMAR1CA1CA2 | |
| SCHEMBL7301359 | 0.86 | ITGB3 (0.37) | CYP26A1ITGB3ITGA2BMCHR1 | |
| SCHEMBL7294732 | 0.85 | DPP4 (0.44) | CYP26A1CYP19A1SIGMAR1CA1CA2 | |
| SCHEMBL7301552 | 0.84 | PREP (0.39) | CYP19A1SIGMAR1ADRA1DADRA1AADRA1B | |
| SCHEMBL7295266 | 0.84 | PREP (0.39) | CYP19A1SIGMAR1ADRA1DADRA1AADRA1B | |
| SCHEMBL7294861 | 0.84 | PREP (0.39) | CYP19A1SIGMAR1ADRA1DADRA1AADRA1B | |
| SCHEMBL7296404 | 0.78 | GAA (0.36) | — | |
| SCHEMBL4621033 | 0.78 | CYP26A1 (0.61) | CYP26A1CYP19A1SIGMAR1CA1CA2 | |
| SCHEMBL7297223 | 0.77 | ITGB3 (0.34) | CYP26A1ITGB3ITGA2BDRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6017929-A | Cholinesterase activator | ZERIA PHARMACEUTICAL CO., LTD. (JP) | 2000-01-25 | — | — | US | disclosed |
| EP-0754454-A1 | CHOLINESTERASE ACTIVATOR | ZERIA PHARMACEUTICAL CO., LTD. (JP) | 1997-01-22 | — | — | EP | disclosed |
| EP-0372484-B1 | Condensed benzene derivative | ZERIA PHARM CO LTD (JP) | 1994-10-26 | — | — | EP | disclosed |
| US-5028604-A | Cognition Activators | ZERIA PHARMACEUTICAL CO., LTD. (JP) | 1991-07-02 | — | — | US | disclosed |
| EP-0372484-A2 | Condensed benzene derivative | ZERIA PHARMACEUTICAL CO., LTD. (JP) | 1990-06-13 | — | — | EP | disclosed |