Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 8/20 | 0.70 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.67 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7301049 | 0.93 | AGTR1 (0.68) | PPARGAGTR1AGTR2 | |
| SCHEMBL7301700 | 0.91 | AGTR1 (0.69) | PPARGAGTR1AGTR2 | |
| SCHEMBL7302131 | 0.89 | PPARG (0.55) | PPARGAGTR1AGTR2 | |
| SCHEMBL8392112 | 0.88 | AGTR1 (0.80) | PPARGAGTR1AGTR2 | |
| SCHEMBL682604 | 0.85 | PPARG (0.71) | PPARG | |
| SCHEMBL7302960 | 0.85 | PPARG (0.68) | PPARGAGTR1 | |
| SCHEMBL8392240 | 0.84 | AGTR1 (0.80) | PPARGAGTR1AGTR2 | |
| SCHEMBL8391692 | 0.84 | AGTR1 (0.83) | PPARGAGTR1AGTR2 | |
| SCHEMBL7054367 | 0.83 | AGTR1 (0.82) | PPARGAGTR1AGTR2 | |
| SCHEMBL7301055 | 0.82 | AGTR1 (0.53) | PPARGAGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614519-A | (1-(2,3 or 4-N-morpholinoalkyl)-imidazol-4-yl)-benizimidazol-1-yl-methyl]-biphenyls useful as angiotensin-II antagonists | KARL THOMAE GMBH (DE) | 1997-03-25 | — | — | US | disclosed |
| US-5602127-A | ADMINISTERING TO TREAT HYPERTENSION | KARL THOMAE GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5594003-A | HYPOTENSIVE AGENTS | DR. KARL THOMAE GMBH (DE) | 1997-01-14 | — | — | US | disclosed |
| US-5591762-A | HYPOTENSIVE AGENTS | DR. KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |
| EP-0502314-A1 | Benzimidazol, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-09-09 | — | — | EP | disclosed |