SCHEMBL7302194

SCHEMBL7302194

O=C(O)[C@H](Cc1ccccc1)NC(=O)C1(CS)CCc2ccccc2C1

nearest known ligand 0.82

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MMP1 P03956 6/20 0.55
MME P08473 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7302528 0.85 FNTA (0.47) MMP1MME
SCHEMBL7291810 0.83 MME (0.42) MMP1MME
SCHEMBL7294573 0.82 MME (0.57) MMP1MME
SCHEMBL7294567 0.82 MME (0.57) MMP1MME
SCHEMBL7293268 0.80 MME (0.48) MMP1MME
SCHEMBL7292661 0.76 MME (0.55) MMP1MME
SCHEMBL20509354 0.76 MME (0.50) MMP1MME
SCHEMBL20509353 0.76 MME (0.50) MMP1MME
SCHEMBL7370871 0.73 MMP1 (0.83) MMP1
SCHEMBL7370872 0.73 MMP1 (0.83) MMP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0516980-B1 Novel 2-mercaptomethylene-tetrahydronaphthalene and indane-2-carboxamide derivatives as enkephalinase inhibitors MERRELL PHARMA INC (US) 1996-04-17 EP disclosed
US-5252601-A 2-mercaptomethylene-tetrahydronaphthalene and indane-2-carboxamide derivatives as enkephalinase inhibitors MERRELL DOW PHARMACEUTICALS INC. (US) 1993-10-12 US disclosed
EP-0516980-A1 Novel 2-mercaptomethylene-tetrahydronaphthalene and indane-2-carboxamide derivatives as enkephalinase inhibitors MERRELL PHARMACEUTICALS INC. (US) 1992-12-09 EP disclosed