Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.54 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | MMP8 | P22894 | 2/20 | 0.36 |
| ▸ | MMP13 | P45452 | 2/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 4/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 4/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7302451 | 1.00 | SIRT2 (0.54) | SIRT2MMP2MMP9MMP8MMP13 | |
| SCHEMBL21125254 | 0.79 | SIRT2 (0.48) | SIRT2MMP2MMP9MMP8MMP13 | |
| SCHEMBL5176907 | 0.77 | LMNA (0.54) | TAS1R3TAS1R1L3MBTL1KMT2A | |
| SCHEMBL28168690 | 0.75 | MEN1 (0.48) | KMT2A | |
| SCHEMBL7308066 | 0.74 | SIRT2 (0.42) | SIRT2MMP2MMP9MMP8MMP13 | |
| SCHEMBL7308075 | 0.74 | SIRT2 (0.42) | SIRT2MMP2MMP9MMP8MMP13 | |
| SCHEMBL22775074 | 0.74 | HDAC1 (0.46) | SIRT2L3MBTL1HDAC1HDAC6 | |
| SCHEMBL29604518 | 0.74 | HDAC1 (0.46) | SIRT2L3MBTL1HDAC1HDAC6 | |
| SCHEMBL13550944 | 0.72 | SIRT2 (0.44) | SIRT2MMP2MMP9MMP8MMP13 | |
| SCHEMBL5737786 | 0.71 | SIRT2 (0.43) | SIRT2MMP2MMP9MMP8MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5594010-A | TREATMENT OF HYPERTENSION AND ATHERIOSCLEROSIS | BAYER AKTIENGESELLSCHAFT (DE) | 1997-01-14 | — | — | US | disclosed |
| EP-0630896-A1 | Substituted mono- and bipyridylmethyl derivatives as angiotensin II antagonist | BAYER AG (DE) | 1994-12-28 | — | — | EP | disclosed |