Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | MMP9 | P14780 | 2/20 | 0.41 |
| ▸ | MMP8 | P22894 | 2/20 | 0.41 |
| ▸ | MMP13 | P45452 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGAV | P06756 | 1/20 | 0.37 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.37 |
| ▸ | MEP1B | Q16820 | 2/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.35 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7308075 | 1.00 | SIRT2 (0.42) | SIRT2MMP2MMP9MMP8MMP13 | |
| SCHEMBL21125254 | 0.90 | SIRT2 (0.48) | SIRT2MMP2MMP9MMP8MMP13 | |
| SCHEMBL7302440 | 0.74 | SIRT2 (0.54) | SIRT2MMP2MMP9MMP8MMP13 | |
| SCHEMBL7302451 | 0.74 | SIRT2 (0.54) | SIRT2MMP2MMP9MMP8MMP13 | |
| SCHEMBL16838929 | 0.73 | LTA4H (0.46) | ALDH1A1MAPTCD274 | |
| SCHEMBL1616321 | 0.72 | ALDH1A1 (0.51) | MMP13ALDH1A1MEP1B | |
| SCHEMBL1525379 | 0.72 | MAOB (0.45) | LMNAMAPT | |
| SCHEMBL22775570 | 0.72 | TACR1 (0.45) | SIRT2ITGB3CPB2 | |
| SCHEMBL29605170 | 0.72 | TACR1 (0.45) | SIRT2ITGB3CPB2 | |
| SCHEMBL2443868 | 0.71 | GAA (0.51) | ALDH1A1TDP1ITGB3ITGB1ITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5594010-A | TREATMENT OF HYPERTENSION AND ATHERIOSCLEROSIS | BAYER AKTIENGESELLSCHAFT (DE) | 1997-01-14 | — | — | US | disclosed |
| EP-0630896-A1 | Substituted mono- and bipyridylmethyl derivatives as angiotensin II antagonist | BAYER AG (DE) | 1994-12-28 | — | — | EP | disclosed |