Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 14/20 | 0.53 |
| ▸ | MMP13 | P45452 | 11/20 | 0.53 |
| ▸ | ADAM17 | P78536 | 8/20 | 0.51 |
| ▸ | MMP2 | P08253 | 2/20 | 0.50 |
| ▸ | MMP3 | P08254 | 2/20 | 0.50 |
| ▸ | MMP9 | P14780 | 2/20 | 0.50 |
| ▸ | MMP8 | P22894 | 2/20 | 0.50 |
| ▸ | ADAMTS7 | Q9UKP4 | 1/20 | 0.49 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.49 |
| ▸ | MMP12 | P39900 | 1/20 | 0.46 |
| ▸ | MMP14 | P50281 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7143961 | 0.94 | MMP1 (0.58) | MMP1MMP13ADAM17MMP2MMP3 | |
| SCHEMBL7141629 | 0.91 | MMP1 (0.56) | MMP1MMP13ADAM17MMP2MMP3 | |
| SCHEMBL7141663 | 0.91 | MMP1 (0.54) | MMP1MMP13ADAM17MMP2MMP3 | |
| SCHEMBL7133708 | 0.89 | MMP1 (0.57) | MMP1MMP13ADAM17 | |
| SCHEMBL7311687 | 0.87 | MMP1 (0.69) | MMP1MMP13ADAM17MMP2MMP3 | |
| SCHEMBL7139183 | 0.85 | MMP1 (0.59) | MMP1MMP13ADAM17MMP2MMP3 | |
| SCHEMBL7305646 | 0.85 | MMP1 (0.51) | MMP1MMP13ADAM17MMP2 | |
| SCHEMBL7141846 | 0.82 | MMP1 (0.58) | MMP1MMP13MMP2MMP3MMP9 | |
| SCHEMBL7133786 | 0.79 | MMP1 (0.58) | MMP1MMP13ADAM17MMP2MMP3 | |
| SCHEMBL7134718 | 0.79 | MMP1 (0.58) | MMP1MMP13ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6214870-B1 | ANTIARTHRITIC AGENTS; ANTICANCER AGENTS | PFIZER INC | 2001-04-10 | — | — | US | disclosed |
| EP-1041072-A1 | Dioxocyclopentyl hydroxamic acids | Pfizer Products Inc. (US) | 2000-10-04 | — | — | EP | disclosed |