Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 2/20 | 0.66 |
| ▸ | HTRA1 | Q92743 | 2/20 | 0.62 |
| ▸ | CTSK | P43235 | 8/20 | 0.61 |
| ▸ | CTSL | P07711 | 7/20 | 0.60 |
| ▸ | CTSB | P07858 | 4/20 | 0.59 |
| ▸ | CTSS | P25774 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7302672 | 1.00 | CAPN1 (0.66) | CAPN1HTRA1CTSKCTSLCTSB | |
| SCHEMBL7761753 | 0.90 | CTSL (0.58) | CAPN1CTSKCTSLCTSBCTSS | |
| SCHEMBL7312791 | 0.85 | CAPN1 (0.69) | CAPN1HTRA1CTSKCTSLCTSB | |
| SCHEMBL7312774 | 0.85 | CAPN1 (0.69) | CAPN1HTRA1CTSKCTSLCTSB | |
| SCHEMBL7327426 | 0.85 | CAPN1 (0.78) | CAPN1HTRA1CTSKCTSLCTSB | |
| SCHEMBL9828791 | 0.85 | CAPN1 (0.78) | CAPN1HTRA1CTSKCTSLCTSB | |
| SCHEMBL27809377 | 0.85 | CAPN1 (0.78) | CAPN1HTRA1CTSKCTSLCTSB | |
| SCHEMBL7315481 | 0.84 | CAPN1 (0.70) | CAPN1HTRA1CTSKCTSLCTSB | |
| SCHEMBL7315453 | 0.84 | CAPN1 (0.70) | CAPN1HTRA1CTSKCTSLCTSB | |
| SCHEMBL7302668 | 0.84 | PSMB1 (0.54) | CAPN1HTRA1CTSKCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525420-B1 | Pseudopeptides and dipeptides characterised by a substituted methyl ketone moiety at the C-terminus as thiol protease inhibitors | MITSUBISHI CHEM CORP (JP) | 1999-05-12 | — | — | EP | disclosed |
| US-5834508-A | PROTEASE ENZYME INHIBITORS; MUSCLE DISORDERS | MITSUBISHI CHEMICAL CORPORATION (JP) | 1998-11-10 | — | — | US | disclosed |
| US-5639783-A | POTENT PROTEASE INHIBITOR FOR TREATING MUSCULAR, NERVOUS SYSTEM DISEASES | MITSUBISHI CHEMICAL CORPORATION (JP) | 1997-06-17 | — | — | US | disclosed |
| EP-0525420-A1 | Pseudopeptides and dipeptides characterised by a substituted methyl ketone moiety at the C-terminus as thiol protease inhibitors | Mitsubishi Chemical Corporation (JP) | 1993-02-03 | — | — | EP | disclosed |