Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 11/20 | 0.74 |
| ▸ | MMP2 | P08253 | 10/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 6/20 | 0.43 |
| ▸ | MMP13 | P45452 | 4/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 4/20 | 0.41 |
| ▸ | MMP7 | P09237 | 3/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7302697 | 1.00 | MMP9 (0.74) | MMP9MMP2SMN1; SMN2MMP1MMP13 | |
| SCHEMBL7305247 | 0.98 | MMP9 (0.70) | MMP9MMP2SMN1; SMN2MMP1MMP13 | |
| SCHEMBL7305528 | 0.85 | MMP9 (1.00) | MMP9MMP2SMN1; SMN2MMP1MMP13 | |
| SCHEMBL7305533 | 0.85 | MMP9 (1.00) | MMP9MMP2SMN1; SMN2MMP1MMP13 | |
| SCHEMBL7308413 | 0.83 | MMP9 (0.95) | MMP9MMP2SMN1; SMN2MMP1MMP13 | |
| SCHEMBL7308416 | 0.83 | MMP9 (0.95) | MMP9MMP2SMN1; SMN2MMP1MMP13 | |
| SCHEMBL31630322 | 0.82 | MMP9 (0.76) | MMP9MMP2SMN1; SMN2MMP1MMP13 | |
| SCHEMBL31630491 | 0.81 | MMP2 (0.74) | MMP9MMP2SMN1; SMN2MMP1MMP13 | |
| SCHEMBL31630255 | 0.81 | MMP2 (0.74) | MMP9MMP2SMN1; SMN2MMP1MMP13 | |
| SCHEMBL27438204 | 0.81 | MMP9 (0.62) | MMP9MMP2SMN1; SMN2MMP1MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |