SCHEMBL7302799

SCHEMBL7302799

CCOC(=O)C1(CCl)CCOCC1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.41
RECQL P46063 1/20 0.38
RAB9A P51151 4/20 0.36
ALDH1A1 P00352 4/20 0.36
KMT2A Q03164 3/20 0.36
POLB P06746 3/20 0.36
LMNA P02545 2/20 0.36
MAPT P10636 2/20 0.36
NPSR1 Q6W5P4 2/20 0.36
HPGD P15428 1/20 0.36
MEN1 O00255 2/20 0.36
GAA P10253 2/20 0.36
MAPK1 P28482 2/20 0.36
NPC1 O15118 1/20 0.36
ATM Q13315 1/20 0.35
CYP3A4 P08684 1/20 0.33
CYP2C19 P33261 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
KDM4E B2RXH2 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11032538 0.87 ALDH1A1 (0.39) ALDH1A1KMT2APOLBLMNAMEN1
SCHEMBL20564117 0.85 TSHR (0.47) TSHRRECQLRAB9AALDH1A1KMT2A
SCHEMBL6782433 0.84 TSHR (0.42) TSHRRECQLRAB9AALDH1A1KMT2A
SCHEMBL16730865 0.83 MEN1 (0.43) RAB9AALDH1A1KMT2APOLBMEN1
SCHEMBL24242177 0.82 TSHR (0.41) TSHRRECQLRAB9AALDH1A1KMT2A
SCHEMBL7308023 0.82 TSHR (0.41) TSHRRECQLRAB9AALDH1A1KMT2A
SCHEMBL1970982 0.82 TSHR (0.41) TSHRRECQLRAB9AALDH1A1KMT2A
SCHEMBL6810064 0.82 TSHR (0.41) TSHRRECQLRAB9AALDH1A1KMT2A
SCHEMBL7301501 0.82 TSHR (0.41) TSHRRECQLRAB9AALDH1A1KMT2A
SCHEMBL23135867 0.81 TSHR (0.43) TSHRRECQLRAB9AALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0780386-B1 Matrix metalloprotease inhibitors HOFFMANN LA ROCHE (CH) 2002-10-02 EP disclosed
US-5932595-A ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT SYNTEX (U.S.A.) INC. (US) 1999-08-03 US disclosed
EP-0780386-A1 Matrix metalloprotease inhibitors F. HOFFMANN-LA ROCHE AG (CH) 1997-06-25 EP disclosed