Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.67 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.67 |
| ▸ | PGR | P06401 | 1/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.67 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.67 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.67 |
| ▸ | CRBN | Q96SW2 | 5/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | OGT | O15294 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7269908 | 0.89 | SLC6A4 (0.78) | SLC6A4NR3C1PGRKCNH2PDE3B | |
| SCHEMBL7267767 | 0.84 | SLC6A4 (0.72) | SLC6A4NR3C1PGRKCNH2PDE3B | |
| SCHEMBL2729628 | 0.82 | NR3C1 (0.69) | SLC6A4NR3C1PGRKCNH2PDE3B | |
| SCHEMBL11046347 | 0.81 | NR3C1 (0.62) | SLC6A4NR3C1PGRKCNH2PDE3B | |
| SCHEMBL9412170 | 0.80 | KCNH2 (0.69) | SLC6A4NR3C1PGRKCNH2PDE3B | |
| SCHEMBL11202877 | 0.80 | SLC6A4 (0.69) | SLC6A4NR3C1PGRKCNH2PDE3B | |
| SCHEMBL11201045 | 0.80 | SLC6A4 (0.69) | SLC6A4NR3C1PGRKCNH2PDE3B | |
| Vesnarinone SCHEMBL6243858 | 0.80 | PDE3B (1.00) | SLC6A4NR3C1PGRKCNH2PDE3B | |
| Vesnarinone SCHEMBL50993 | 0.80 | PDE3B (1.00) | SLC6A4NR3C1PGRKCNH2PDE3B | |
| Vesnarinone SCHEMBL29402965 | 0.80 | PDE3B (1.00) | SLC6A4NR3C1PGRKCNH2PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0370381-B1 | 2(1H)-quinolinone compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-05-10 | — | — | EP | disclosed |
| US-4988698-A | Cardiovascular disorders, hypotensive agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-01-29 | — | — | US | disclosed |