Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPA1 | P15085 | 4/20 | 0.51 |
| ▸ | CPA3 | P15088 | 2/20 | 0.51 |
| ▸ | CPB1 | P15086 | 1/20 | 0.51 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | MIF | P14174 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MME | P08473 | 2/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | XIAP | P98170 | 1/20 | 0.39 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 2/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7308314 | 0.94 | CPA1 (0.58) | CPA1CPA3CPB1CPB2MIF | |
| SCHEMBL7297423 | 0.88 | CPA1 (0.51) | CPA1CPA3CPB1CPB2MIF | |
| SCHEMBL7301712 | 0.86 | CPA1 (0.50) | CPA1CPA3CPB1CPB2MIF | |
| SCHEMBL7301205 | 0.85 | MME (0.46) | MMELTA4H | |
| SCHEMBL7302641 | 0.84 | PPARG (0.51) | CPA1CPA3CPB1CPB2ALDH1A1 | |
| SCHEMBL6823946 | 0.82 | PPARG (0.52) | CPA1CPA3CPB1CPB2PKM | |
| SCHEMBL7310081 | 0.82 | CPA1 (0.49) | CPA1CPA3CPB1CPB2MIF | |
| SCHEMBL27462683 | 0.78 | PPARG (0.53) | CPA1CPA3CPB1CPB2ALDH1A1 | |
| SCHEMBL7309312 | 0.78 | SLC6A4 (0.41) | SLC6A4 | |
| SCHEMBL7300405 | 0.78 | MME (0.50) | MMELTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |