Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 2/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | ANPEP | P15144 | 1/20 | 0.48 |
| ▸ | ECE1 | P42892 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | FCER2 | P06734 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7301205 | 0.94 | MME (0.46) | MMELTA4HANPEPECE1MEN1 | |
| SCHEMBL7301831 | 0.91 | MMP9 (0.47) | MMELTA4HANPEPECE1MMP1 | |
| SCHEMBL7299278 | 0.88 | PPARG (0.47) | MMELTA4HANPEPECE1MMP1 | |
| SCHEMBL6823210 | 0.87 | MMP1 (0.59) | HDAC8MMP1 | |
| SCHEMBL7298887 | 0.86 | ANPEP (0.52) | MMELTA4HANPEPECE1FCER2 | |
| SCHEMBL7312804 | 0.84 | MMP1 (0.50) | HDAC6MMP1 | |
| SCHEMBL7308314 | 0.83 | CPA1 (0.58) | MMELTA4H | |
| SCHEMBL27479584 | 0.83 | PPARG (0.49) | MMELTA4HANPEPECE1HDAC6 | |
| SCHEMBL7302523 | 0.82 | MMP1 (0.54) | MEN1KMT2AMMP1 | |
| SCHEMBL6822907 | 0.81 | HDAC1 (0.52) | HDAC8HDAC6MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |