Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 6/20 | 0.51 |
| ▸ | PPARA | Q07869 | 6/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.49 |
| ▸ | CPA1 | P15085 | 2/20 | 0.47 |
| ▸ | CPB1 | P15086 | 1/20 | 0.47 |
| ▸ | CPA3 | P15088 | 1/20 | 0.47 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.47 |
| ▸ | MMP12 | P39900 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6823946 | 0.87 | PPARG (0.52) | PPARGPPARACPA1CPB1CPA3 | |
| SCHEMBL7299278 | 0.87 | PPARG (0.47) | PPARGPPARAMMP12MMP13NPY5R | |
| SCHEMBL7308314 | 0.86 | CPA1 (0.58) | FFAR1CPA1CPB1CPA3CPB2 | |
| SCHEMBL7297423 | 0.84 | CPA1 (0.51) | PPARGPPARAFFAR1CPA1CPB1 | |
| SCHEMBL7302912 | 0.84 | CPA1 (0.51) | CPA1CPB1CPA3CPB2ALDH1A1 | |
| SCHEMBL7301712 | 0.82 | CPA1 (0.50) | CPA1CPB1CPA3CPB2MMP13 | |
| SCHEMBL7310105 | 0.81 | PPARG (0.42) | PPARGPPARAFFAR1MMP13NPY5R | |
| SCHEMBL7310081 | 0.81 | CPA1 (0.49) | PPARGPPARACPA1CPB1CPA3 | |
| SCHEMBL7301821 | 0.81 | ALDH1A1 (0.48) | PPARGPPARAALDH1A1 | |
| SCHEMBL6823578 | 0.80 | MMP12 (0.48) | PPARGPPARAFFAR1MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |