Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.45 |
| ▸ | CDC25B | P30305 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308521 | 1.00 | LMNA (0.58) | LMNATAAR1PTPN1CDC25BTSHR | |
| SCHEMBL883429 | 1.00 | LMNA (0.58) | LMNATAAR1PTPN1CDC25BTSHR | |
| SCHEMBL16464737 | 0.85 | LMNA (0.46) | LMNATAAR1PTPN1CDC25BTSHR | |
| SCHEMBL17022722 | 0.85 | LMNA (0.56) | LMNATAAR1PTPN1CDC25BTSHR | |
| SCHEMBL25933760 | 0.81 | MGLL (0.42) | LMNAL3MBTL1 | |
| SCHEMBL16397855 | 0.81 | TAAR1 (0.50) | LMNATAAR1TSHRAKT1 | |
| SCHEMBL4265685 | 0.80 | LMNA (0.47) | LMNATAAR1TSHRHRH4HRH3 | |
| SCHEMBL21410396 | 0.79 | MAPT (0.40) | LMNA | |
| SCHEMBL8051039 | 0.79 | TSHR (0.33) | LMNATSHR | |
| SCHEMBL27463829 | 0.79 | LMNA (0.52) | LMNATAAR1PTPN1CDC25BTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657440-B1 | Oxazolidine-2-one derivatives as MAO inhibitors | HOFFMANN LA ROCHE (CH) | 2000-04-05 | — | — | EP | disclosed |
| US-5574055-A | COGNITIVE AND NEURODEGENERATIVE DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1996-11-12 | — | — | US | disclosed |
| EP-0657440-A1 | Oxazolidine-2-one derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1995-06-14 | — | — | EP | disclosed |