Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 3/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | EDNRB | P24530 | 2/20 | 0.43 |
| ▸ | EDNRA | P25101 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7583505 | 0.92 | PGR (0.52) | PGRMAPTEDNRBEDNRA | |
| SCHEMBL7582149 | 0.87 | EDNRB (0.57) | EDNRBEDNRA | |
| SCHEMBL7294848 | 0.84 | EDNRA (0.61) | EDNRBEDNRA | |
| SCHEMBL7991567 | 0.76 | EDNRA (0.62) | EDNRBEDNRA | |
| SCHEMBL8395710 | 0.75 | EDNRB (0.45) | PGRGPR119EDNRBEDNRA | |
| SCHEMBL7298473 | 0.75 | DHPS (0.47) | MAPT | |
| SCHEMBL7296697 | 0.74 | EDNRA (0.56) | EDNRBEDNRA | |
| SCHEMBL7596382 | 0.74 | EDNRA (0.65) | EDNRBEDNRA | |
| SCHEMBL7293947 | 0.74 | EDNRA (0.56) | EDNRBEDNRA | |
| SCHEMBL9423875 | 0.74 | EDNRA (0.46) | MAPTEDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | disclosed |
| US-5292740-A | Sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | disclosed |