Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | NPY1R | P25929 | 1/20 | 0.57 |
| ▸ | NPY2R | P49146 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.44 |
| ▸ | ADRB3 | P13945 | 7/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 6/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7297332 | 0.91 | LMNA (0.47) | LMNANPY1RNPY2RMAPTKMT2A | |
| SCHEMBL7305413 | 0.91 | LMNA (0.47) | LMNANPY1RNPY2RMAPTKMT2A | |
| SCHEMBL7294156 | 0.91 | ADRB2 (0.54) | LMNANPY1RNPY2RMAPTKMT2A | |
| SCHEMBL7296778 | 0.83 | ATM (0.45) | LMNANPY1RNPY2RMAPTKMT2A | |
| SCHEMBL7303245 | 0.82 | ADRB2 (0.48) | LMNANPY1RNPY2RMAPTKMT2A | |
| SCHEMBL7331432 | 0.82 | ADRB2 (0.48) | LMNANPY1RNPY2RMAPTKMT2A | |
| SCHEMBL9688163 | 0.82 | ADRB2 (0.43) | LMNANPY1RNPY2RMAPTKMT2A | |
| SCHEMBL7302577 | 0.82 | LMNA (0.53) | LMNANPY1RNPY2RMAPTKMT2A | |
| SCHEMBL9686910 | 0.82 | ADRB2 (0.47) | LMNANPY1RNPY2RMAPTKMT2A | |
| SCHEMBL7337397 | 0.82 | ADRB2 (0.47) | LMNANPY1RNPY2RMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |