Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.51 |
| ▸ | ELANE | P08246 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2816778 | 0.86 | FFAR1 (0.50) | PPARAALDH1A1RAB9ANPC1L3MBTL1 | |
| SCHEMBL7308291 | 0.85 | MAPK13 (0.42) | PPARAELANEALDH1A1SRD5A2MAPK13 | |
| SCHEMBL7350612 | 0.80 | BLM (0.43) | ALDH1A1HPGD | |
| SCHEMBL8101750 | 0.78 | SMN1; SMN2 (0.49) | ALDH1A1RAB9ANPC1L3MBTL1 | |
| SCHEMBL11356807 | 0.78 | ALDH1A1 (0.54) | ELANEALDH1A1SRD5A2MAPK13MAPK12 | |
| SCHEMBL11306067 | 0.77 | ALDH1A1 (0.58) | ALDH1A1SRD5A2MAPK13MAPK12MAPK11 | |
| SCHEMBL7722382 | 0.77 | ALDH1A1 (0.58) | ELANEALDH1A1SRD5A2MAPK13MAPK12 | |
| SCHEMBL2026670 | 0.74 | FFAR1 (0.48) | ALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL15007027 | 0.74 | FFAR1 (0.70) | ELANEALDH1A1SRD5A2MAPK13MAPK12 | |
| SCHEMBL27910293 | 0.74 | ALDH1A1 (0.54) | ELANEALDH1A1SRD5A2MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |