Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.42 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.42 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.42 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.42 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303734 | 0.85 | PPARA (0.51) | MAPK13MAPK12MAPK11MAPK14NPY5R | |
| SCHEMBL7301182 | 0.73 | MMP2 (0.54) | MMP8MMP1MMP2MMP13ELANE | |
| SCHEMBL11356807 | 0.73 | ALDH1A1 (0.54) | MAPK13MAPK12MAPK11MAPK14NPY5R | |
| SCHEMBL7722382 | 0.72 | ALDH1A1 (0.58) | MAPK13MAPK12MAPK11MAPK14NPY5R | |
| SCHEMBL11306067 | 0.72 | ALDH1A1 (0.58) | MAPK13MAPK12MAPK11MAPK14HDAC1 | |
| SCHEMBL2816778 | 0.71 | FFAR1 (0.50) | PPARAALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL15007027 | 0.70 | FFAR1 (0.70) | MAPK13MAPK12MAPK11MAPK14NPY5R | |
| SCHEMBL2026670 | 0.70 | FFAR1 (0.48) | ALDH1A1HPGDRAB9A | |
| SCHEMBL27910293 | 0.70 | ALDH1A1 (0.54) | MAPK13MAPK12MAPK11MAPK14NPY5R | |
| SCHEMBL15908065 | 0.69 | ALDH1A1 (0.45) | PPARAALDH1A1ELANEHPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |