Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7313232 | 0.85 | ADRB2 (0.55) | KDM4ESMN1; SMN2DRD2DRD1ALDH1A1 | |
| SCHEMBL7303821 | 0.78 | KDM4E (0.49) | KDM4ESMN1; SMN2BIRC5DRD2DRD1 | |
| SCHEMBL9446670 | 0.74 | KDM4E (0.60) | KDM4ESMN1; SMN2BIRC5DRD2DRD1 | |
| SCHEMBL10806875 | 0.72 | BIRC5 (0.48) | KDM4ESMN1; SMN2BIRC5DRD2DRD1 | |
| SCHEMBL9827018 | 0.72 | ADRB2 (0.50) | KDM4EBIRC5DRD2DRD1DRD3 | |
| SCHEMBL327061 | 0.71 | ALDH1A1 (0.45) | KDM4EALDH1A1LMNACYP1A2CYP2C19 | |
| SCHEMBL7940396 | 0.71 | HPGD (0.57) | KDM4ESMN1; SMN2BIRC5ALDH1A1CYP1A2 | |
| SCHEMBL2422374 | 0.71 | ALDH1A1 (0.65) | KDM4ESMN1; SMN2BIRC5DRD2DRD1 | |
| SCHEMBL2524984 | 0.71 | TSHR (0.48) | KDM4EALDH1A1KMT2ATDP1CYP3A4 | |
| SCHEMBL7310908 | 0.70 | TSHR (0.54) | KDM4ESMN1; SMN2DRD2DRD1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5773456-A | EMPHYSEMA, RHEUMATOID ARTHRITIS AND PANCREATITIS | SANOFI (FR) | 1998-06-30 | — | — | US | disclosed |
| US-5464852-A | Used in treatment of degenerative diseases | STERLING WINTHROP INC. (US) | 1995-11-07 | — | — | US | disclosed |
| US-5380737-A | Enzyme inhibitors | STERLING WINTHROP INC. (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0542371-A1 | Saccharin derivative proteolytic enzyme inhibitors | STERLING WINTHROP INC. (US) | 1993-05-19 | — | — | EP | disclosed |