Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 13/20 | 0.76 |
| ▸ | CTSK | P43235 | 4/20 | 0.48 |
| ▸ | CTSS | P25774 | 2/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303925 | 1.00 | MMP13 (0.76) | MMP13CTSKCTSSMMP1MMP2 | |
| SCHEMBL7310335 | 0.92 | MMP13 (0.65) | MMP13CTSKCTSSMMP1MMP2 | |
| SCHEMBL7308069 | 0.87 | MMP13 (1.00) | MMP13CTSKCTSSMMP1 | |
| SCHEMBL7308056 | 0.87 | MMP13 (1.00) | MMP13CTSKCTSSMMP1 | |
| SCHEMBL7180333 | 0.85 | MMP13 (0.82) | MMP13CTSKCTSSMMP1 | |
| SCHEMBL7308292 | 0.82 | MMP13 (0.61) | MMP13MMP1MMP2 | |
| SCHEMBL7302646 | 0.81 | CA2 (0.52) | MMP13CTSKCTSSCTSLCTSB | |
| SCHEMBL7302654 | 0.81 | CA2 (0.52) | MMP13CTSKCTSSCTSLCTSB | |
| SCHEMBL7299964 | 0.80 | MMP13 (0.82) | MMP13CTSKCTSSMMP1MMP2 | |
| SCHEMBL7301636 | 0.79 | MMP13 (0.57) | MMP13MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |