Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 17/20 | 0.50 |
| ▸ | AGTR2 | P50052 | 8/20 | 0.48 |
| ▸ | EDNRA | P25101 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303878 | 0.96 | AGTR1 (0.55) | AGTR1AGTR2EDNRA | |
| SCHEMBL7300842 | 0.85 | AGTR1 (0.57) | AGTR1AGTR2EDNRA | |
| SCHEMBL7304124 | 0.85 | AGTR1 (0.47) | AGTR1AGTR2 | |
| SCHEMBL8848056 | 0.85 | AGTR1 (0.70) | AGTR1AGTR2 | |
| SCHEMBL8848168 | 0.84 | AGTR1 (0.52) | AGTR1AGTR2 | |
| SCHEMBL8789960 | 0.84 | PPARG (0.47) | — | |
| SCHEMBL7301961 | 0.81 | AGTR1 (0.56) | AGTR1AGTR2 | |
| SCHEMBL8789745 | 0.81 | RORC (0.40) | EDNRA | |
| SCHEMBL7302623 | 0.81 | AGTR1 (0.57) | AGTR1AGTR2EDNRA | |
| SCHEMBL8847551 | 0.81 | AGTR1 (0.58) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614519-A | (1-(2,3 or 4-N-morpholinoalkyl)-imidazol-4-yl)-benizimidazol-1-yl-methyl]-biphenyls useful as angiotensin-II antagonists | KARL THOMAE GMBH (DE) | 1997-03-25 | — | — | US | disclosed |
| US-5602127-A | ADMINISTERING TO TREAT HYPERTENSION | KARL THOMAE GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5594003-A | HYPOTENSIVE AGENTS | DR. KARL THOMAE GMBH (DE) | 1997-01-14 | — | — | US | disclosed |
| US-5591762-A | HYPOTENSIVE AGENTS | DR. KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |
| EP-0502314-A1 | Benzimidazol, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-09-09 | — | — | EP | disclosed |