Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 15/20 | 0.62 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7204802 | 0.86 | DHPS (0.57) | DHPSALDH1A1MAPK1HTTL3MBTL1 | |
| SCHEMBL5632471 | 0.86 | DHPS (0.57) | DHPSALDH1A1MAPK1HTTL3MBTL1 | |
| SCHEMBL5631299 | 0.80 | DHPS (0.52) | DHPSALDH1A1MAPK1HTTL3MBTL1 | |
| SCHEMBL7297418 | 0.80 | DHPS (0.52) | DHPSALDH1A1MAPK1HTTL3MBTL1 | |
| SCHEMBL7303389 | 0.80 | DHPS (0.81) | DHPSALDH1A1HTT | |
| SCHEMBL7330437 | 0.80 | DHPS (0.59) | DHPSALDH1A1MAPK1HTTL3MBTL1 | |
| SCHEMBL7197670 | 0.79 | DHPS (0.51) | DHPSALDH1A1MAPK1HTTL3MBTL1 | |
| SCHEMBL618135 | 0.79 | DHPS (0.58) | DHPS | |
| SCHEMBL29770374 | 0.79 | DHPS (0.58) | DHPS | |
| SCHEMBL9681693 | 0.79 | HSP90AA1 (0.60) | DHPSHSP90AA1HSP90AB1ALDH1A1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | disclosed |
| US-5292740-A | Sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | disclosed |