Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 6/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPY1R | P25929 | 1/20 | 0.43 |
| ▸ | NPY2R | P49146 | 1/20 | 0.43 |
| ▸ | MIF | P14174 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7297671 | 0.81 | PDE3B (0.53) | PDE3BPDE3AMAPTLMNANPY1R | |
| SCHEMBL18522739 | 0.75 | MAPT (0.41) | PDE3BPDE3AMAPTLMNANPY1R | |
| SCHEMBL15284610 | 0.74 | ESRRB (0.58) | MAPTLMNAMIFSMN1; SMN2CA1 | |
| SCHEMBL14679418 | 0.74 | HPGD (0.57) | MAPTLMNAKMT2ACA1CA2 | |
| SCHEMBL14155336 | 0.73 | LMNA (0.56) | LMNAKMT2ASMN1; SMN2CA1CA2 | |
| SCHEMBL4881326 | 0.72 | PDE3B (0.42) | PDE3BPDE3ALMNASMN1; SMN2PDE4A | |
| SCHEMBL8339349 | 0.72 | SMN1; SMN2 (0.55) | PDE3BPDE3AMAPTLMNANPY1R | |
| SCHEMBL14679377 | 0.70 | HPGD (0.62) | MAPTLMNAKMT2ACA1CA2 | |
| SCHEMBL10474306 | 0.70 | MAPT (0.65) | PDE3BPDE3AMAPTLMNANPY1R | |
| SCHEMBL7240480 | 0.69 | BCL2 (0.53) | MAPTLMNAKMT2ABCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |