Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | FNTA | P49354 | 2/20 | 0.39 |
| ▸ | FNTB | P49356 | 2/20 | 0.39 |
| ▸ | PGGT1B | P53609 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GNPAT | O15228 | 1/20 | 0.36 |
| ▸ | CTSC | P53634 | 3/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7307479 | 0.89 | FOLH1 (0.42) | FOLH1GAANPSR1CYP2C19FNTA | |
| SCHEMBL7307301 | 0.84 | CYP2C19 (0.51) | FOLH1GAANPSR1CYP2C19LMNA | |
| SCHEMBL7296774 | 0.83 | MME (0.44) | FOLH1GNPATCTSSCTSK | |
| SCHEMBL7307291 | 0.77 | ACE (0.52) | CYP2C19 | |
| SCHEMBL7344601 | 0.74 | MME (0.41) | GNPATCTSSCTSK | |
| SCHEMBL8881003 | 0.74 | GAA (0.46) | GAANPSR1LMNARAB9A | |
| SCHEMBL9229018 | 0.74 | GAA (0.46) | GAANPSR1LMNARAB9A | |
| SCHEMBL8880999 | 0.74 | GAA (0.46) | GAANPSR1LMNARAB9A | |
| SCHEMBL7281365 | 0.72 | ALDH1A1 (0.59) | GAALMNAGNPAT | |
| SCHEMBL7281335 | 0.72 | ALDH1A1 (0.59) | GAALMNAGNPAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657453-B1 | Angiotensin converting enzyme (ace) inhibitors containing a fused multiple ring lactam | BRISTOL MYERS SQUIBB CO (US) | 1999-01-20 | — | — | EP | disclosed |
| US-5637698-A | ANGIOTENSIN CONVERTING ENZYME AND NEUTRAL ENDOPEPTIDASE INHIBITOR | BRISTOL-MYERS SQUIBB CO. (US) | 1997-06-10 | — | — | US | disclosed |
| US-5525723-A | INHIBITORS OF ANGIOTENSIN CONVERTING ENZYME, NEUTRAL ENDOPEPTIDASE | BRISTOL-MYERS SQUIBB CO. (US) | 1996-06-11 | — | — | US | disclosed |
| EP-0657453-A1 | Angiotensin converting enzyme (ace) inhibitors containing a fused multiple ring lactam | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-06-14 | — | — | EP | disclosed |