Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.40 |
| ▸ | CTSC | P53634 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7304968 | 0.84 | FOLH1 (0.44) | CYP2C19GAANPSR1LMNARAB9A | |
| SCHEMBL7307479 | 0.83 | FOLH1 (0.42) | CYP2C19GAANPSR1LMNAGLA | |
| SCHEMBL7265100 | 0.80 | ALDH1A1 (0.56) | GAANPSR1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL7272751 | 0.80 | ALDH1A1 (0.56) | GAANPSR1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL7301260 | 0.78 | MME (0.44) | GAANPSR1RAB9AALDH1A1MEN1 | |
| SCHEMBL8883750 | 0.77 | ALDH1A1 (0.64) | CYP2C19GAANPSR1TP53ALDH1A1 | |
| SCHEMBL8883742 | 0.77 | ALDH1A1 (0.64) | CYP2C19GAANPSR1TP53ALDH1A1 | |
| SCHEMBL11360473 | 0.76 | ALDH1A1 (0.47) | GAANPSR1RAB9ATP53ALDH1A1 | |
| SCHEMBL3505431 | 0.75 | ALDH1A1 (0.43) | CYP2C19GAANPSR1RAB9AALDH1A1 | |
| SCHEMBL23513652 | 0.74 | CYP2C19 (0.64) | CYP2C19LMNARAB9AALDH1A1FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657453-B1 | Angiotensin converting enzyme (ace) inhibitors containing a fused multiple ring lactam | BRISTOL MYERS SQUIBB CO (US) | 1999-01-20 | — | — | EP | disclosed |
| US-5637698-A | ANGIOTENSIN CONVERTING ENZYME AND NEUTRAL ENDOPEPTIDASE INHIBITOR | BRISTOL-MYERS SQUIBB CO. (US) | 1997-06-10 | — | — | US | disclosed |
| US-5525723-A | INHIBITORS OF ANGIOTENSIN CONVERTING ENZYME, NEUTRAL ENDOPEPTIDASE | BRISTOL-MYERS SQUIBB CO. (US) | 1996-06-11 | — | — | US | disclosed |
| EP-0657453-A1 | Angiotensin converting enzyme (ace) inhibitors containing a fused multiple ring lactam | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-06-14 | — | — | EP | disclosed |