Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 2/20 | 0.46 |
| ▸ | CTSK | P43235 | 2/20 | 0.46 |
| ▸ | REN | P00797 | 11/20 | 0.38 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
| ▸ | CTSE | P14091 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10448350 | 1.00 | CTSS (0.46) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL10407971 | 1.00 | CTSS (0.46) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL7299781 | 0.83 | CTSS (0.45) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL7264769 | 0.82 | CTSS (0.50) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL10407740 | 0.82 | CTSS (0.50) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL7274874 | 0.82 | CTSS (0.46) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL9819706 | 0.82 | CTSS (0.46) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL7272354 | 0.82 | CTSS (0.46) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL10777312 | 0.82 | CTSS (0.46) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL7273164 | 0.81 | CTSK (0.53) | CTSSCTSKRENCTSDCTSE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0417698-B1 | Amino acid derivatives having renin-inhibiting activity, process for their preparation, agents containing them, and their use | HOECHST AG (DE) | 1996-03-13 | — | — | EP | disclosed |
| US-5374731-A | Treatment of high blood pressure, congestive heart failure and viral disorders | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-12-20 | — | — | US | disclosed |
| US-5360791-A | Renin-inhibiting aminodiol derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-11-01 | — | — | US | disclosed |
| US-5346887-A | Mixture of tripeptide renin inhibitor and steroid antiinflammatory agent | ABBOTT LABORATORIES (US) | 1994-09-13 | — | — | US | disclosed |
| EP-0370454-B1 | Renin-inhibiting amino diol derivatives | HOECHST AG (DE) | 1994-04-20 | — | — | EP | disclosed |
| US-5268374-A | Containing both amide and hydroxy groups | ABBOTT LABORATORIES (US) | 1993-12-07 | — | — | US | disclosed |
| EP-0519434-A2 | Heterocyclic compounds with renin inhibiting properties, process for their preparation and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-12-23 | — | — | EP | disclosed |
| US-5059589-A | Glaucoma treatment | ABBOTT LABORATORIES (US) | 1991-10-22 | — | — | US | disclosed |
| EP-0415981-A4 | RETROVIRAL PROTEASE INHIBITORS | — | 1991-10-09 | — | — | EP | disclosed |
| US-5036051-A | Renin inhibitors | ABBOTT LABORATORIES (US) | 1991-07-30 | — | — | US | disclosed |
| US-4994477-A | Hypotensive agents | ABBOTT LABORATORIES (US) | 1991-02-19 | — | — | US | disclosed |
| US-4977277-A | INTERMEDIATES FOR RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1990-12-11 | — | — | US | disclosed |
| EP-0394853-A1 | Dipeptide-derivatives with enzym-inhibiting activity | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-10-31 | — | — | EP | disclosed |
| US-4927807-A | RENIN INHIBITING AMIDES | ABBOTT LABORATORIES (US) | 1990-05-22 | — | — | US | disclosed |
| WO-1990003971-A1 | NON-PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1990-04-19 | — | — | WO | disclosed |
| EP-0342541-A2 | Retroviral protease inhibitors | ABBOTT LABORATORIES (US) | 1989-11-23 | — | — | EP | disclosed |
| WO-1989010752-A1 | RETROVIRAL PROTEASE INHIBITORS | ABBOTT LABORATORIES (US) | 1989-11-16 | — | — | WO | disclosed |
| US-4837204-A | RENIN INHIBITORS; HYPOTENSIVE AGENTS | ABBOTT LABORATORIES (US) | 1989-06-06 | — | — | US | disclosed |
| EP-0311012-A2 | Glaucoma treatment | ABBOTT LABORATORIES (US) | 1989-04-12 | — | — | EP | disclosed |
| EP-0230266-A2 | Functionalized peptidyl aminodiols and -triols | ABBOTT LABORATORIES (US) | 1987-07-29 | — | — | EP | disclosed |