Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KHK | P50053 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | ESRRG | P62508 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6621053 | 0.83 | SMN1; SMN2 (0.97) | KMT2AHPGDSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL6621926 | 0.83 | SMN1; SMN2 (0.97) | KMT2AHPGDSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL6621057 | 0.83 | SMN1; SMN2 (0.97) | KMT2AHPGDSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL240518 | 0.78 | HTR2C (0.62) | HTR2CSLC18A3 | |
| Hydrochloric Acid SCHEMBL377800 | 0.76 | HTR2C (0.63) | HTR2CSLC18A3 | |
| SCHEMBL6960571 | 0.75 | KMT2A (0.44) | KMT2AHPGDSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL1066184 | 0.75 | KDM1A (0.48) | HTR2C | |
| SCHEMBL18161913 | 0.75 | KDM1A (0.48) | HTR2C | |
| Trifluoroacetic Acid SCHEMBL7330887 | 0.75 | KMT2A (0.74) | KMT2AHPGDSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL7970183 | 0.74 | TRPC3 (0.48) | KMT2AKDM4EMEN1ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153611-A | AS NON-DOPAMINERGIC ANTIISCHEMIC COMPOUNDS FOR TREATING BRAIN DISORDERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-11-28 | — | — | US | disclosed |
| US-5595993-A | Antischemic piperazinyl- and piperidinyl-cyclohexanes | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-01-21 | — | — | US | disclosed |
| EP-0560669-B1 | Piperazinyl-and piperidinyl-cyclohexenes and cyclohexanes | BRISTOL MYERS SQUIBB CO (US) | 1995-06-14 | — | — | EP | disclosed |
| US-5352678-A | Dopaminergic agents | BRISTOL-MYERS SQUIBB CO. (US) | 1994-10-04 | — | — | US | disclosed |
| EP-0560669-A1 | Piperazinyl-and piperidinyl-cyclohexenes and cyclohexanes | Bristol-Myers Squibb Company (US) | 1993-09-15 | — | — | EP | disclosed |