Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.97 |
| ▸ | HPGD | P15428 | 1/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | SLC18A3 | Q16572 | 3/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.60 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.56 |
| ▸ | KHK | P50053 | 1/20 | 0.53 |
| ▸ | TRPV6 | Q9H1D0 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6621057 | 1.00 | SMN1; SMN2 (0.97) | SMN1; SMN2HPGDKMT2ACYP2D6CYP2C19 | |
| SCHEMBL6621926 | 1.00 | SMN1; SMN2 (0.97) | SMN1; SMN2HPGDKMT2ACYP2D6CYP2C19 | |
| Trifluoroacetic Acid SCHEMBL7330887 | 0.87 | KMT2A (0.74) | SMN1; SMN2HPGDKMT2ACYP2D6CYP2C19 | |
| SCHEMBL15184744 | 0.83 | CYP2D6 (0.83) | SMN1; SMN2HPGDKMT2ACYP2D6CYP2C19 | |
| SCHEMBL7305035 | 0.83 | KMT2A (0.69) | SMN1; SMN2HPGDKMT2ACYP2D6CYP2C19 | |
| SCHEMBL2965273 | 0.83 | SLC18A3 (0.81) | SMN1; SMN2HPGDKMT2ACYP2D6CYP2C19 | |
| SCHEMBL24163290 | 0.81 | SLC18A3 (0.79) | SMN1; SMN2HPGDKMT2ACYP2D6CYP2C19 | |
| SCHEMBL28702035 | 0.81 | CYP2D6 (0.93) | SMN1; SMN2HPGDKMT2ACYP2D6CYP2C19 | |
| SCHEMBL21121132 | 0.80 | HPGD (0.65) | SMN1; SMN2HPGDKMT2ACYP2D6CYP2C19 | |
| Bromobenzene SCHEMBL27620594 | 0.80 | KMT2A (0.65) | SMN1; SMN2HPGDKMT2ACYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210317134-A1 | UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 7 (USP7) MODULATORS AND USES THEREOF | RAPT THERAPEUTICS INC (US) | 2021-10-14 | — | — | US | disclosed |
| EP-0891332-B1 | 6-PHENYLPYRIDYL-2-AMINE DERIVATIVES | PFIZER (US) | 2004-03-17 | — | — | EP | disclosed |
| US-6465491-B2 | NITRIC OXIDE SYNTHASE INHIBITOR; NERVOUS SYSTEM DISORDERS | PFIZER INC. | 2002-10-15 | — | — | US | disclosed |
| US-20010034348-A1 | 6-phenylpyridyl-2-amine derivatives | LOWE JOHN A (US) | 2001-10-25 | — | — | US | disclosed |
| US-6235747-B1 | NITRIC OXIDE SYNTHASE INHIBITOR | PFIZER INC. | 2001-05-22 | — | — | US | disclosed |
| EP-0891332-A1 | 6-PHENYLPYRIDYL-2-AMINE DERIVATIVES | PFIZER INC. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036871-A1 | 6-PHENYLPYRIDYL-2-AMINE DERIVATIVES | PFIZER INC. (US) | 1997-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010034348-A1 | 6-phenylpyridyl-2-amine derivatives | NOS2, NOS3, NOS1 | SMN1; SMN2 655/4885HPGD 136/4885KMT2A 1323/4885 |
| US-20210317134-A1 | UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 7 (USP7) MODULATORS AND USES THEREOF | USP7, SENP7, USP8 | SMN1; SMN2 3154/4885HPGD 3395/4885KMT2A 2614/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.