Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | COMT | P21964 | 1/20 | 0.37 |
| ▸ | MLYCD | O95822 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7294976 | 0.86 | HPGD (0.40) | HPGDTDP1HSP90AA1HSP90AB1LMNA | |
| SCHEMBL7421174 | 0.86 | HPGD (0.40) | HPGDTDP1HSP90AA1HSP90AB1LMNA | |
| SCHEMBL13991796 | 0.76 | KDM4E (0.41) | HPGDHSP90AA1HSP90AB1LMNAMEN1 | |
| SCHEMBL2334415 | 0.74 | HPGD (0.46) | HPGDTDP1HSP90AA1HSP90AB1LMNA | |
| SCHEMBL1020497 | 0.74 | ALDH1A1 (0.43) | TDP1SMN1; SMN2TSHRPOLBKEAP1 | |
| SCHEMBL3599082 | 0.74 | KEAP1 (0.42) | TDP1MEN1KMT2AKDM4EKEAP1 | |
| SCHEMBL11358159 | 0.74 | TSHR (0.42) | KMT2ASMN1; SMN2TSHRKDM4EMAPK1 | |
| SCHEMBL12677875 | 0.72 | HPGD (0.51) | HPGDTDP1HSP90AA1HSP90AB1LMNA | |
| SCHEMBL31330707 | 0.72 | ERN1 (0.42) | HPGDTDP1HSP90AA1HSP90AB1LMNA | |
| SCHEMBL471668 | 0.72 | HPGD (0.51) | HPGDTDP1HSP90AA1HSP90AB1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0550111-B1 | 2-Saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and pharmaceutical compositions containing them | SANOFI SA (FR) | 1999-04-14 | — | — | EP | disclosed |
| US-5856349-A | 2-Saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof | SANOFI (FR) | 1999-01-05 | — | — | US | disclosed |
| US-5783589-A | 2-saccharinylmethyl aryl and arloxy acetates useful as proteolytic enzyme inhibitors and compositions and method of use thereof | SANOFI (FR) | 1998-07-21 | — | — | US | disclosed |
| US-5652254-A | TREATMENT OF DEGENERATIVE DISEASES, RHEUMATOID ARTHRITIS, PSORIASIS, CYSTIC FIBROSIS | SANOFI, S.A. (FR) | 1997-07-29 | — | — | US | disclosed |
| US-5597841-A | 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof | STERLING WINTHROP, INC. (US) | 1997-01-28 | — | — | US | disclosed |
| US-5563163-A | TREATMENT OF DEGENERATIVE DISEASES | STERLING WINTHROP, INC. (US) | 1996-10-08 | — | — | US | disclosed |
| US-5512589-A | TREATING DEGENERATIVE DISEASES | STERLING WINTHROP INC. (US) | 1996-04-30 | — | — | US | disclosed |
| US-5489604-A | TREATING DEGENERATIVE DISEASES | STERLING WINTHROP, INC. (US) | 1996-02-06 | — | — | US | disclosed |
| US-5488062-A | 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof | STERLING WINTHROP INC. (US) | 1996-01-30 | — | — | US | disclosed |
| US-5385923-A | Treatment of degenerative diseases | STERLING WINTHROP INC. (US) | 1995-01-31 | — | — | US | disclosed |
| US-5376653-A | A protease enzyme inhibitor for treating degenerative diseases , respiratory system disorders, rheumatoid arthritis and pancreatitis | STERLING WINTHROP INC. (US) | 1994-12-27 | — | — | US | disclosed |
| US-5306818-A | Treating degenerative diseases such as emphysema, rheumatoid arthritis and pancreatitis | STERLING WINTHROP INC. (US) | 1994-04-26 | — | — | US | disclosed |
| EP-0550111-A1 | 2-Saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and pharmaceutical compositions containing them | STERLING WINTHROP INC. (US) | 1993-07-07 | — | — | EP | disclosed |
| EP-0550112-A1 | 2-Saccharinylmethyl aryl and aryloxy acetates useful as proteolytic enzyme inhibitors and pharmaceutical compositions contaning them | STERLING WINTHROP INC. (US) | 1993-07-07 | — | — | EP | disclosed |
| US-5128339-A | Emphysema, rheumatoid arthritis, pancreatitis | STERLING WINTHROP INC. (US) | 1992-07-07 | — | — | US | disclosed |
| EP-0483928-A1 | 2-Saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use | STERLING WINTHROP INC. (US) | 1992-05-06 | — | — | EP | disclosed |