Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 19/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7317706 | 1.00 | REN (0.52) | RENMMP2MMP9MMP8 | |
| SCHEMBL10477904 | 0.94 | REN (0.49) | RENMMP2MMP9MMP8 | |
| SCHEMBL10477848 | 0.93 | REN (0.52) | RENMMP2MMP9MMP8 | |
| SCHEMBL7309704 | 0.93 | REN (0.48) | RENMMP2MMP9MMP8 | |
| SCHEMBL10477766 | 0.92 | REN (0.54) | RENMMP2MMP9MMP8 | |
| SCHEMBL10571933 | 0.89 | REN (0.49) | RENMMP2MMP9MMP8 | |
| SCHEMBL10477882 | 0.88 | REN (0.52) | RENMMP2MMP9MMP8 | |
| SCHEMBL10868525 | 0.88 | REN (0.58) | REN | |
| SCHEMBL10868511 | 0.88 | REN (0.58) | REN | |
| SCHEMBL8484484 | 0.86 | MMP9 (0.47) | RENMMP2MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135914-A | Controlling hypertension, hyperaldosteronism, and congestive heart failure | WARNER-LAMBERT COMPANY (US) | 1992-08-04 | — | — | US | claimed |
| US-5135914-A | Controlling hypertension, hyperaldosteronism, and congestive heart failure | WARNER-LAMBERT COMPANY (US) | 1992-08-04 | — | — | US | disclosed |