Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 10/20 | 0.69 |
| ▸ | PDE4A | P27815 | 7/20 | 0.69 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.69 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.69 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.69 |
| ▸ | MMP2 | P08253 | 6/20 | 0.69 |
| ▸ | MMP3 | P08254 | 5/20 | 0.69 |
| ▸ | MMP13 | P45452 | 11/20 | 0.52 |
| ▸ | MMP7 | P09237 | 4/20 | 0.52 |
| ▸ | MMP12 | P39900 | 4/20 | 0.52 |
| ▸ | ACE | P12821 | 3/20 | 0.52 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7299010 | 0.88 | MMP1 (0.76) | MMP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7313243 | 0.87 | MMP2 (0.51) | MMP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7302153 | 0.86 | MMP2 (0.73) | MMP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7310358 | 0.84 | MMP1 (0.70) | MMP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7310353 | 0.84 | MMP1 (0.70) | MMP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7308096 | 0.83 | MMP1 (0.57) | MMP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7308283 | 0.82 | MMP1 (0.80) | MMP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6824624 | 0.81 | MMP2 (1.00) | MMP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7302160 | 0.80 | PDE4A (0.69) | MMP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27477108 | 0.79 | MMP1 (0.45) | MMP1PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |