Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 11/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7309612 | 0.94 | PDE4B (0.52) | PDE4BEGFRMAPTLMNAHTT | |
| SCHEMBL4052027 | 0.90 | PDE4B (0.54) | PDE4BKDM4ELMNAHTTHTR2C | |
| SCHEMBL4049841 | 0.88 | TBXAS1 (0.49) | PDE4BLMNAHTTHTR2CMEN1 | |
| SCHEMBL4056450 | 0.87 | PDE4B (0.46) | PDE4BLMNAHTTHTR2CMEN1 | |
| SCHEMBL4050499 | 0.86 | PDE4B (0.46) | PDE4BLMNAHTTHTR2CMEN1 | |
| SCHEMBL7314230 | 0.85 | PDE4B (0.52) | PDE4BADORA2AADORA2BADORA1 | |
| SCHEMBL4055355 | 0.84 | RECQL (0.51) | PDE4BHTT | |
| SCHEMBL7308904 | 0.84 | PDE4B (0.56) | PDE4BMEN1KMT2AADORA2AADORA2B | |
| SCHEMBL7304940 | 0.83 | PDE4B (0.59) | PDE4BADORA2AADORA2BADORA1 | |
| SCHEMBL7316189 | 0.83 | PDE4B (0.57) | PDE4BKDM4EMAPTLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2394998-A1 | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2011-12-14 | — | — | EP | disclosed |
| EP-2394998-A1 | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2011-12-14 | — | — | EP | disclosed |