Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 2/20 | 0.31 |
| ▸ | CDC14B | O60729 | 1/20 | 0.31 |
| ▸ | CDC14A | Q9UNH5 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7302829 | 0.76 | — | — | |
| SCHEMBL5250113 | 0.75 | KDM4E (0.33) | KDM4ESMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL14932033 | 0.72 | HSD11B1 (0.41) | KDM4ESMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL7305961 | 0.72 | KDM4E (0.40) | KDM4ESMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL7297470 | 0.70 | KDM4E (0.40) | KDM4ESMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL18241857 | 0.69 | KDM4E (0.43) | KDM4ESMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL7181355 | 0.67 | KDM4E (0.38) | KDM4ESMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL7306208 | 0.67 | KDM4E (0.35) | KDM4ESMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL2000756 | 0.66 | HSD11B1 (0.46) | KDM4ESMN1; SMN2ALDH1A1LMNAPOLB | |
| SCHEMBL7309102 | 0.66 | BACE1 (0.39) | KDM4ESMN1; SMN2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5629406-A | AMINO ACID DERIVATIVES | SANKYO COMPANY, LIMITED (JP) | 1997-05-13 | — | — | US | disclosed |
| EP-0587311-A1 | Peptides capable of inhibiting the activity of HIV protease, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1994-03-16 | — | — | EP | disclosed |